The nail plate is generated by the nail matrix at the proximal portion of the nail bed ( Figure 1). The nail plate is the hard keratin cover of the dorsal portion of the distal phalanx. Rheumatoid arthritis, SLE, dermatomyositis, scleroderma
Subacute bacterial endocarditis, SLE, rheumatoid arthritis, antiphospholipid syndrome, peptic ulcer disease, malignancies, oral contraceptive use, pregnancy, psoriasis, trauma Melanoma, benign nevus, chemical staining, normal variant in darkly pigmented peopleĪlopecia areata, vitiligo, atopic dermatitis, psoriasis Hepatolenticular degeneration (Wilson’s disease), silver poisoning, quinacrine therapyĪrsenic poisoning, Hodgkin’s disease, CHF, leprosy, malaria, chemotherapy, carbon monoxide poisoning, other systemic insults Hepatic failure, cirrhosis, diabetes mellitus, CHF, hyperthyroidism, malnutrition Lymphedema, pleural effusion, immunodeficiency, bronchiectasis, sinusitis, rheumatoid arthritis, nephrotic syndrome, thyroiditis, tuberculosis, Raynaud’s disease Psoriasis, Reiter’s syndrome, incontinentia pigmenti, alopecia areataĪny severe systemic illness that disrupts nail growth, Raynaud’s disease, pemphigus, trauma Psoriasis, infection, hyperthyroidism, sarcoidosis, trauma, amyloidosis, connective tissue disorders Iron deficiency anemia, hemochromatosis, Raynaud’s disease, SLE, trauma, nail-patella syndrome Inflammatory bowel disease, pulmonary malignancy, asbestosis, chronic bronchitis, COPD, cirrhosis, congenital heart disease, endocarditis, atrioventricular malformations, fistulas
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